In contrast, nevus-associated melanomas were found significantly less frequently in patients with 1 or more previous melanomas (0.28 P =. 04), or with the diagnosis of in situ melanoma (14.01 P <. In univariate analyses, reported as odds ratios (95% CIs), nevus-associated melanomas were found significantly more frequently in patients of lower melanoma risk (risk group 1, 2.75 P =. Most nevus-associated melanomas were found on the trunk (67 ) however, statistical significance for the localization was not present (P =. Histopathologic examination revealed remnants of melanocytic nevi in 103 melanomas (54.2%). The median (SD) Breslow thickness of invasive melanomas was 0.42 (0.43) mm. Evaluation was performed at regular intervals between April 1, 1997, and May 31, 2012, and data analysis was conducted between September 1, 2012, and December 31, 2013.Īssessment of the frequency of nevus-associated melanoma and the influence of patient- and melanoma-related factors on their manifestation.ĭuring the study, 190 melanomas (81 in situ and 109 invasive) were diagnosed in 113 of the 832 patients (13.6%) there were 42 women (37.2%) and 71 men (62.8%). Participants included 832 patients at high risk for developing melanoma. To identify the frequency of nevus-associated melanomas and correlate patient- and melanoma-related factors.Ī prospective, single-center, observational study with systematic documentation of melanoma risk factors, clinical and dermoscopic criteria of excised lesions, and results of histopathologic examination was conducted at a university-based dermatology clinic. However, earlier histopathologic studies were limited by their retrospective design and did not assess the influence of important patient-related risk factors. The reported frequencies of associations between primary cutaneous melanomas and melanocytic nevi vary widely between 4% and 72%.
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